Variations of Prostate-Specific Antigen and Cytokines in Patients with Benign Prostatic Hyperplasia

The etiology of benign prostatic hyperplasia (BPH) is still obscure. Data supporting an interaction connecting prostate hyperplasia and immune disregulation is accumulating. Serum levels of pro-inflammatory and antiinflammatory cytokines measured by enzyme-linked immunosorbent assay in 3 groups of patients with BPH. The groups included 12 men who had mean prostate specific antigen (PSA) serum concentration 95±13 ng/ml, 14 man, with mean PSA 4,4±1,2 ng/ml and 11 man, with mean PSA 10,7±2,3 ng/ml. It was found that level of anti-inflammatory cytokine IL-4 significantly elevated while amount of pro-inflammatory IFNgamma did not change. The increase of IL-4 correlated with a level PSA and maximum quantity was found in the patients 3 groups. Our study indicates that a high level of IL-4 is directly associated with elevated PSA with severities of BPH.